DOCK9-DT

Across TCGA pan-cancer cohorts, DOCK9-DT RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DOCK9-DT’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DOCK9-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DOCK9-DT is over-expressed in tumor, although a few such as LUAD and KIRP show the opposite, repressed pattern.

THCA, LUAD, and KIRP are the cancer types where DOCK9-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DOCK9-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	+1.798	<.001	11	view →
LUAD	Male	II,III,IV	−1.022	<.001	9	view →
KIRP	Male	II,III,IV	−1.060	<.001	7	view →
UCEC	All	III,IV	−1.731	<.001	6	view →
KICH	All	All	−0.949	<.001	6	view →
KIRC	Male	II,III,IV	−0.666	<.001	6	view →
BRCA	All	All	−0.629	<.001	6	view →
HNSC	All	II,III,IV	−0.462	.002	6	view →
LIHC	Female	II,III,IV	+0.764	<.001	5	view →
READ	All	II,III,IV	−0.607	.004	3	view →
CHOL	All	All	+0.966	<.001	2	view →
STAD	All	II,III,IV	−0.550	.045	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DOCK9-DT–THCA

Open the THCA breakdown →