DOCK8

Across TCGA patient cohorts, DOCK8 RNA expression is significantly associated with the protein abundance of many other proteins, with 22,584 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DOCK8-associated proteins across cancer lineages are PTPRC, SKAP2, and HCLS1. Each is linked with DOCK8 in more than 9 cancer types. Because this analysis shows association rather than direction, both DOCK8-to-partner and partner-to-DOCK8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DOCK8 versus PTPRC in GBM, with a Pearson correlation of 0.84.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK8→partner) and Y-score (partner→DOCK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTPRC →	+0.883	+1.098	<.001	<.001	3	10
GBM	SKAP2 →	+0.865	+1.034	<.001	<.001	3	10
GBM	HCLS1 →	+0.926	+1.124	<.001	<.001	3	10
GBM	IL16 →	+0.741	+1.017	<.001	<.001	3	10
LSCC	ITGAL →	+0.682	+0.977	<.001	<.001	3	10
GBM	LCP1 →	+0.892	+0.900	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,584 associations by consensus.

DOCK8 vs PTPRC — GBM

Explore this scatter interactively →