DOCK8

Across TCGA patient cohorts, DOCK8 protein abundance is significantly associated with the RNA expression of many other genes, with 20,680 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DOCK8-associated genes across cancer lineages are CYTH4, APOBEC3H, and GRAP2. Each is linked with DOCK8 in more than 9 cancer types. Because this analysis shows association rather than direction, both DOCK8-to-partner and partner-to-DOCK8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DOCK8 versus CYTH4 in GBM, with a Pearson correlation of 0.88.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK8→partner) and Y-score (partner→DOCK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CYTH4 →	+1.312	+0.713	<.001	<.001	3	10
UCEC	APOBEC3H →	+0.846	+0.596	<.001	<.001	3	10
HNSC	GRAP2 →	+0.860	+0.415	<.001	<.001	3	10
GBM	NCF4 →	+1.377	+0.712	<.001	<.001	3	10
BRCA	IL2RB →	+1.246	+0.396	<.001	<.001	3	10
BRCA	SLA2 →	+1.098	+0.476	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,680 associations by consensus.

DOCK8 vs CYTH4 — GBM

Explore this scatter interactively →