DOCK8

Across TCGA patient cohorts, DOCK8 mutation is significantly associated with the RNA expression of many other genes, with 6,568 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOCK8-associated genes across cancer lineages are CNOT6, SRSF4, and DHDDS. Each is linked with DOCK8 in more than 3 cancer types. Because this analysis shows association rather than direction, both DOCK8-to-partner and partner-to-DOCK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNOT6 grouped by DOCK8-low versus DOCK8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK8→partner) and Y-score (partner→DOCK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CNOT6 →	+0.298	+2.190	.003	.001	3	4
UCEC	SRSF4 →	+0.391	+1.874	<.001	<.001	3	4
SKCM	DHDDS →	+0.318	+1.860	.003	.001	3	4
UCEC	DCLRE1B →	+0.482	+1.472	<.001	<.001	3	4
UCEC	ZWINT →	+0.751	+1.450	<.001	<.001	3	4
UCEC	SPRYD7 →	+0.431	+2.201	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,568 associations by consensus.

CNOT6 by DOCK8 expression — COAD

Explore this box plot interactively →