DOCK6

Across TCGA patient cohorts, DOCK6 mutation is significantly associated with the RNA expression of many other genes, with 5,482 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOCK6-associated genes across cancer lineages are EMID1, EXOSC8, and TXNL4A. Each is linked with DOCK6 in more than 3 cancer types. Because this analysis shows association rather than direction, both DOCK6-to-partner and partner-to-DOCK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EMID1 grouped by DOCK6-low versus DOCK6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK6→partner) and Y-score (partner→DOCK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EMID1 →	-0.878	-1.574	<.001	<.001	3	4
UCEC	EXOSC8 →	+0.263	+1.595	.003	.002	3	4
UCEC	TXNL4A →	+0.271	+3.290	.001	<.001	3	4
UCEC	TSPY26P →	-0.577	-2.115	<.001	<.001	3	4
UCEC	AP3S1 →	+0.300	+1.726	.005	.001	3	4
STAD	NDUFS5 →	+0.395	+2.840	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,482 associations by consensus.

EMID1 by DOCK6 expression — UCEC

Explore this box plot interactively →