DOCK6

Across TCGA cell cohorts, DOCK6 mutation is significantly associated with the RNA expression of many other genes, with 1,241 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOCK6-associated genes across cancer lineages are ZNF430, ADPRM, and FANCG. Each is linked with DOCK6 in more than 2 cancer types. Because this analysis shows association rather than direction, both DOCK6-to-partner and partner-to-DOCK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF430 grouped by DOCK6-low versus DOCK6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK6→partner) and Y-score (partner→DOCK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF430 →	+0.524	+3.410	.004	.002	3	3
LARGE_INTESTINE	ADPRM →	+0.590	+3.459	<.001	<.001	3	3
LARGE_INTESTINE	FANCG →	+0.467	+2.036	.003	.002	3	3
URINARY_TRACT	KCNU1 →	+0.063	+3.906	<.001	.009	3	2
CNS	CCDC195 →	+0.218	+4.044	<.001	.003	3	2
BLOOD_Leukemia	SPRTN →	+0.462	+2.614	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,241 associations by consensus.

ZNF430 by DOCK6 expression — BLOOD_Leukemia

Explore this box plot interactively →