DOCK11

Across TCGA cell cohorts, DOCK11 mutation is significantly associated with the RNA expression of many other genes, with 240 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOCK11-associated genes across cancer lineages are OR6J1, CARNMT1, and OR13D1. Each is linked with DOCK11 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOCK11-to-partner and partner-to-DOCK11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6J1 grouped by DOCK11-low versus DOCK11-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK11→partner) and Y-score (partner→DOCK11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR6J1 →	+0.034	+3.700	<.001	.001	3	2
LARGE_INTESTINE	CARNMT1 →	+0.624	+3.064	.002	.009	3	2
LUNG_SCLC	OR13D1 →	+0.048	+4.269	<.001	.005	3	2
BREAST	ZNRF4 →	+0.015	+3.781	<.001	.009	3	2
STOMACH	IL22 →	+0.035	+4.285	<.001	.007	3	1
STOMACH	LRRC72 →	+0.070	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 240 associations by consensus.

OR6J1 by DOCK11 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →