DOCK11

Across TCGA pan-cancer cohorts, DOCK11 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated DOCK11 data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher DOCK11 RNA is associated with better overall survival. In most high-consensus cancer types, elevated DOCK11 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and UVM are the cancer types where DOCK11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.402	0.261	<.001	94	view →
HNSC	DFS	Median	All	0.442	0.245	<.001	82	view →
UVM	DFS	Tertile	II,III,IV	0.377	0.896	<.001	79	view →
LGG	OS	Median	All	0.375	0.520	<.001	44	view →
SCLC	DFS	Median	All	0.586	0.268	<.001	40	view →
KIRC	DFS	Median	III,IV	0.754	0.516	.006	38	view →
BLCA	OS	Tertile	II,III,IV	0.545	0.677	.016	33	view →
COAD	DFS	Median	III,IV	0.576	0.804	.003	17	view →
LIHC	DFS	Median	III,IV	0.562	0.259	.002	16	view →
ESCA	OS	Median	All	1.000	0.629	.012	10	view →
DLBC	DFS	Median	All	0.626	0.917	.010	9	view →
KICH	DFS	Tertile	II,III,IV	0.662	1.000	.011	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

DOCK11–SKCM (OS)

Open the SKCM breakdown →