DOCK11

Across TCGA cell cohorts, DOCK11 mutation is significantly associated with the mutation status of many other genes, with 4,501 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOCK11-associated genes across cancer lineages are TNRC6A, ADGRB3, and POLE. Each is linked with DOCK11 in more than 7 cancer types. Because this analysis shows association rather than direction, both DOCK11-to-partner and partner-to-DOCK11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNRC6A grouped by DOCK11-low versus DOCK11-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK11→partner) and Y-score (partner→DOCK11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TNRC6A →	+3.930	+3.632	.003	.003	1	8
STOMACH	ADGRB3 →	+3.584	+3.584	.006	.006	1	7
OVARY	POLE →	+3.345	+3.345	.007	.007	1	6
UPPER_AERODIGESTIVE_TRACT	ADGRV1 →	+2.731	+4.070	.009	.009	1	6
OVARY	PCDH17 →	+5.345	+4.632	<.001	<.001	1	6
BLOOD_Lymphoma	KIAA0232 →	+4.014	+4.969	.008	.008	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,501 associations by consensus.

TNRC6A by DOCK11 expression — OVARY

Explore this box plot interactively →