DOCK10

Across TCGA patient cohorts, DOCK10 protein abundance is significantly associated with the RNA expression of many other genes, with 18,761 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DOCK10-associated genes across cancer lineages are CYTH4, APOBEC3H, and GRAP2. Each is linked with DOCK10 in more than 9 cancer types. Because this analysis shows association rather than direction, both DOCK10-to-partner and partner-to-DOCK10 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DOCK10 versus CYTH4 in HNSC, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK10→partner) and Y-score (partner→DOCK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CYTH4 →	+0.955	+0.386	<.001	<.001	3	10
BRCA	APOBEC3H →	+0.721	+0.315	<.001	<.001	3	10
HNSC	GRAP2 →	+0.931	+0.414	<.001	<.001	3	10
HNSC	IL2RB →	+1.181	+0.572	<.001	<.001	3	10
HNSC	TNFSF13B →	+1.063	+0.529	<.001	<.001	3	10
HNSC	IL21R →	+1.155	+0.607	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,761 associations by consensus.

DOCK10 vs CYTH4 — HNSC

Explore this scatter interactively →