DOCK10

Across TCGA patient cohorts, DOCK10 mutation is significantly associated with the RNA expression of many other genes, with 7,463 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOCK10-associated genes across cancer lineages are BCCIP, HPGDS, and ARL6IP1. Each is linked with DOCK10 in more than 4 cancer types. Because this analysis shows association rather than direction, both DOCK10-to-partner and partner-to-DOCK10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCCIP grouped by DOCK10-low versus DOCK10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK10→partner) and Y-score (partner→DOCK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BCCIP →	+0.330	+2.052	<.001	<.001	3	5
LUAD	HPGDS →	-0.660	-2.321	.008	.001	3	4
UCEC	ARL6IP1 →	+0.427	+1.444	<.001	<.001	3	4
UCEC	EXO1 →	+0.408	+1.510	.002	<.001	3	4
UCEC	NDUFAB1 →	+0.428	+2.108	<.001	<.001	3	4
UCEC	R3HDM1 →	+0.241	+0.946	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,463 associations by consensus.

BCCIP by DOCK10 expression — UCEC

Explore this box plot interactively →