DOCK10

Across TCGA patient cohorts, DOCK10 mutation is significantly associated with the total protein of many other genes, with 89 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOCK10-associated genes across cancer lineages are eIF4E, FASN, and PRDX1. Each is linked with DOCK10 in more than 3 cancer types. Because this analysis shows association rather than direction, both DOCK10-to-partner and partner-to-DOCK10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DOCK10-low versus DOCK10-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK10→partner) and Y-score (partner→DOCK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eIF4E →	+0.259	+3.021	.001	.017	3	4
LUSC	FASN →	+0.777	+3.709	<.001	<.001	3	4
LUAD	PRDX1 →	+0.221	+2.807	.045	.003	3	4
STAD	4E-BP1 →	+0.471	+2.321	<.001	.034	3	4
UCEC	eEF2 →	+0.196	+1.392	.023	.015	3	4
COAD	GAPDH →	+0.600	+2.008	.003	.018	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

eIF4E by DOCK10 expression — STAD

Explore this box plot interactively →