DOC2B

Across TCGA patient cohorts, DOC2B protein abundance is significantly associated with the RNA expression of many other genes, with 509 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DOC2B-associated genes across cancer lineages are CARD10, NEFH, and CHGA. Each is linked with DOC2B in more than 1 cancer types. Because this analysis shows association rather than direction, both DOC2B-to-partner and partner-to-DOC2B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DOC2B versus CARD10 in GBM, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOC2B→partner) and Y-score (partner→DOC2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CARD10 →	+0.693	+0.627	.002	.005	3	1
GBM	NEFH →	+1.383	+0.595	.001	.003	3	1
GBM	CHGA →	+2.386	+0.716	<.001	<.001	3	1
GBM	SLC32A1 →	+1.377	+0.595	<.001	.003	3	1
GBM	PPP1R16B →	+1.844	+0.592	<.001	.003	3	1
GBM	CELF4 →	+1.846	+0.924	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 509 associations by consensus.

DOC2B vs CARD10 — GBM

Explore this scatter interactively →