DOC2B

Across TCGA pan-cancer cohorts, DOC2B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DOC2B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DOC2B RNA is repressed in tumor relative to normal tissue. In most cancer types DOC2B is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and BLCA are the cancer types where DOC2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DOC2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.367	<.001	12	view →
KICH	Male	All	−3.080	<.001	11	view →
BLCA	All	IV	−1.504	<.001	9	view →
HNSC	All	III,IV	−1.382	.004	8	view →
THCA	All	II,III,IV	−0.876	<.001	8	view →
KIRP	Male	All	−2.374	<.001	7	view →
LIHC	Female	All	+0.821	<.001	7	view →
BRCA	All	III,IV	−1.845	<.001	6	view →
COAD	All	All	−0.573	<.001	5	view →
READ	All	III,IV	+0.464	.002	4	view →
CHOL	All	All	+1.655	.003	2	view →
UCEC	All	All	−1.430	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DOC2B–KIRC

Open the KIRC breakdown →