DOC2B

Across TCGA patient cohorts, DOC2B mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOC2B-associated genes across cancer lineages are Ku80 and Notch1. Each is linked with DOC2B in more than 1 cancer types. Because this analysis shows association rather than direction, both DOC2B-to-partner and partner-to-DOC2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by DOC2B-low versus DOC2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOC2B→partner) and Y-score (partner→DOC2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.324	+2.820	.025	.036	3	1
UCEC	Notch1 →	+0.233	+2.820	.006	.035	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Ku80 by DOC2B expression — UCEC

Explore this box plot interactively →