DNTTIP2

Across TCGA pan-cancer cohorts, DNTTIP2 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated DNTTIP2 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DNTTIP2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNTTIP2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and COAD show a favorable association.

CCRCC, LSCC, and COAD are the cancer types where DNTTIP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.758	0.972	.001	36	view →
LSCC	DFS	Quartile	II,III,IV	0.933	0.438	.005	12	view →
COAD	DFS	Median	III,IV	1.000	0.898	.047	6	view →
GBM	OS	Tertile	All	0.567	0.269	.024	5	view →
OV	DFS	Median	All	0.861	1.000	.030	4	view →
LUAD	DFS	Tertile	II,III,IV	0.917	0.610	.028	3	view →
PDAC	DFS	Median	III,IV	0.334	0.687	.035	3	view →
HNSC	DFS	Quartile	III,IV	0.891	1.000	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

DNTTIP2–CCRCC (DFS)

Open the CCRCC breakdown →