DNTTIP2

Across TCGA patient cohorts, DNTTIP2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNTTIP2-associated genes across cancer lineages are Notch1, PKC-b-II_pS660, and Shc_pY317. Each is linked with DNTTIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNTTIP2-to-partner and partner-to-DNTTIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by DNTTIP2-low versus DNTTIP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNTTIP2→partner) and Y-score (partner→DNTTIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.218	+3.000	<.001	.001	3	2
UCEC	PKC-b-II_pS660 →	-0.257	-2.115	.024	.017	3	2
UCEC	Shc_pY317 →	-0.223	-2.459	<.001	.018	3	2
UCEC	CDK1 →	+0.141	+3.183	.024	.009	3	2
UCEC	eEF2 →	+0.334	+3.321	.023	.009	3	1
UCEC	EGFR_pY1068 →	-0.340	-3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Notch1 by DNTTIP2 expression — UCEC

Explore this box plot interactively →