DNTTIP2

Across TCGA cell cohorts, DNTTIP2 mutation is significantly associated with the mutation status of many other genes, with 2,890 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNTTIP2-associated genes across cancer lineages are CCDC73, OR7D2, and IARS1. Each is linked with DNTTIP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNTTIP2-to-partner and partner-to-DNTTIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC73 grouped by DNTTIP2-low versus DNTTIP2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNTTIP2→partner) and Y-score (partner→DNTTIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CCDC73 →	+6.277	+6.277	<.001	<.001	1	3
CNS	OR7D2 →	+5.277	+4.459	.005	.005	1	3
CNS	IARS1 →	+5.277	+4.459	.005	.005	1	3
CNS	PRRC2A →	+3.862	+4.347	.001	.001	1	3
LUNG_NSCLC_LUAD	FLRT3 →	+5.339	+4.772	.004	.004	1	3
LUNG_NSCLC_LUAD	AKAP9 →	+2.754	+4.189	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,890 associations by consensus.

CCDC73 by DNTTIP2 expression — CNS

Explore this box plot interactively →