DNTTIP2

Across TCGA cell cohorts, DNTTIP2 mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNTTIP2-associated genes across cancer lineages are Vismodegib, 150412, and KRAS (G12C) Inhibitor-12. Each is linked with DNTTIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNTTIP2-to-partner and partner-to-DNTTIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vismodegib grouped by DNTTIP2-low versus DNTTIP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNTTIP2→partner) and Y-score (partner→DNTTIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Vismodegib →	+0.317	+2.807	.024	.046	3	1
LARGE_INTESTINE	150412 →	+0.435	+3.192	.003	.007	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.468	+3.061	.038	.010	3	1
LARGE_INTESTINE	Cisplatin →	+0.604	+2.807	.021	.032	2	1
LARGE_INTESTINE	729189 →	+0.232	+2.684	.046	.035	2	1
LARGE_INTESTINE	CP724714 →	+0.415	+3.067	.005	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Vismodegib by DNTTIP2 expression — LARGE_INTESTINE

Explore this box plot interactively →