DNMT3B

Across TCGA pan-cancer cohorts, DNMT3B mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated DNMT3B data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DNMT3B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DNMT3B expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC are the cancer types where DNMT3B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.942	0.730	.044	3	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

DNMT3B–LSCC (OS)

Open the LSCC breakdown →