DNMT3B

Across TCGA patient cohorts, DNMT3B protein abundance is significantly associated with the RNA expression of many other genes, with 2,248 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNMT3B-associated genes across cancer lineages are DSCC1, KIF15, and CDC25A. Each is linked with DNMT3B in more than 2 cancer types. Because this analysis shows association rather than direction, both DNMT3B-to-partner and partner-to-DNMT3B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DNMT3B versus DSCC1 in BRCA, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMT3B→partner) and Y-score (partner→DNMT3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DSCC1 →	+1.251	+0.935	.001	.004	3	3
UCEC	KIF15 →	+1.323	+0.477	<.001	<.001	3	3
UCEC	CDC25A →	+1.144	+0.514	<.001	<.001	3	3
UCEC	CDKN3 →	+1.004	+0.615	<.001	<.001	3	2
LSCC	VRK1 →	+0.838	+1.149	.003	<.001	3	2
UCEC	GINS1 →	+1.021	+0.598	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,248 associations by consensus.

DNMT3B vs DSCC1 — BRCA

Explore this scatter interactively →