DNMT3B

Across TCGA patient cohorts, DNMT3B mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNMT3B-associated genes across cancer lineages are c-Met_pY1235, 4E-BP1_pT37_T46, and Caspase-8. Each is linked with DNMT3B in more than 2 cancer types. Because this analysis shows association rather than direction, both DNMT3B-to-partner and partner-to-DNMT3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by DNMT3B-low versus DNMT3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMT3B→partner) and Y-score (partner→DNMT3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.074	+1.483	<.001	.003	3	3
SKCM	4E-BP1_pT37_T46 →	-0.736	-3.169	<.001	.017	3	2
UCEC	Caspase-8 →	-0.267	-1.736	<.001	<.001	3	2
UCEC	C-Raf →	+0.190	+3.247	<.001	<.001	3	2
UCEC	FASN →	+0.231	+1.247	.041	.041	3	2
UCEC	FoxM1 →	+0.153	+0.999	.039	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

c-Met_pY1235 by DNMT3B expression — UCEC

Explore this box plot interactively →