DNMT3B

Across TCGA cell cohorts, DNMT3B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,024 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible DNMT3B-associated GO terms across cancer lineages are Regulation of DNA repair, Regulation of RNA stability, and Regulation of mRNA catabolic process. Each is linked with DNMT3B in more than 13 cancer types. Because this analysis shows association rather than direction, both DNMT3B-to-partner and partner-to-DNMT3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by DNMT3B-low versus DNMT3B-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMT3B→partner) and Y-score (partner→DNMT3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of DNA repair →	+0.084	+1.910	<.001	<.001	3	14
SOFT_TISSUE	Regulation of RNA stability →	+0.083	+1.592	<.001	<.001	3	14
STOMACH	Regulation of mRNA catabolic process →	+0.069	+2.116	<.001	<.001	3	14
BREAST	DNA strand elongation involved in DNA replication →	+0.157	+1.376	<.001	<.001	3	13
SOFT_TISSUE	Double-strand break repair via homologous recombination →	+0.095	+1.755	<.001	<.001	3	13
STOMACH	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.267	+2.051	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,024 associations by consensus.

Regulation of DNA repair by DNMT3B expression — LIVER

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