DNM3-IT1

Across TCGA pan-cancer cohorts, DNM3-IT1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated DNM3-IT1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher DNM3-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DNM3-IT1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LIHC show a favorable association.

KIRP, COAD, and DLBC are the cancer types where DNM3-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.890	0.987	<.001	93	view →
COAD	OS	Tertile	All	0.656	0.867	<.001	69	view →
DLBC	OS	Quartile	III,IV	0.120	0.797	.004	41	view →
UVM	DFS	Quartile	III,IV	0.285	0.786	.003	30	view →
PAAD	OS	Tertile	All	0.724	0.426	.012	22	view →
LIHC	OS	Quartile	II,III,IV	0.854	0.654	.002	21	view →
CESC	OS	Tertile	IV	0.848	0.186	.018	20	view →
OV	DFS	Quartile	II,III,IV	0.331	0.417	.029	18	view →
LAML	DFS	Quartile	All	0.406	0.730	.010	18	view →
UCS	OS	Tertile	IV	0.844	0.283	.030	12	view →
ACC	DFS	Quartile	All	0.119	0.518	.007	6	view →
BLCA	DFS	Quartile	IV	0.261	0.425	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

DNM3-IT1–KIRP (OS)

Open the KIRP breakdown →