DNM3-IT1

Across TCGA pan-cancer cohorts, DNM3-IT1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of DNM3-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where DNM3-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DNM3-IT1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

BRCA, CHOL, and KICH are the cancer types where DNM3-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNM3-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	+0.182	<.001	6	view →
CHOL	Male	All	+0.375	<.001	4	view →
KICH	All	All	−0.121	.004	3	view →
LUSC	Female	III,IV	+0.615	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

DNM3-IT1–BRCA

Open the BRCA breakdown →