DNM1P5

Across TCGA pan-cancer cohorts, DNM1P5 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated DNM1P5 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher DNM1P5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DNM1P5 expression acts as an unfavorable survival marker, although some lineages such as LGG show a favorable association.

MESO, BRCA, and OV are the cancer types where DNM1P5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	II,III,IV	0.071	0.572	<.001	72	view →
BRCA	DFS	Tertile	III,IV	0.259	0.799	<.001	72	view →
OV	OS	Tertile	II,III,IV	0.355	0.847	.001	54	view →
KIRP	OS	Tertile	II,III,IV	0.176	0.743	.007	36	view →
LGG	DFS	Tertile	All	0.662	0.382	.001	21	view →
BLCA	DFS	Tertile	All	0.226	0.616	.039	18	view →
SKCM	DFS	Tertile	All	0.058	0.757	<.001	18	view →
LUAD	OS	Tertile	II,III,IV	0.276	0.594	.017	18	view →
THYM	DFS	Tertile	All	0.563	0.910	.018	9	view →
UCEC	OS	Tertile	All	0.720	0.874	.046	6	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

DNM1P5–MESO (OS)

Open the MESO breakdown →