DNM1P46

Across TCGA pan-cancer cohorts, DNM1P46 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DNM1P46 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher DNM1P46 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DNM1P46 expression acts as an unfavorable survival marker.

BRCA, PRAD, and UCEC are the cancer types where DNM1P46 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.107	0.578	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LGG	DFS	Median	All	0.555	0.832	<.001	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DNM1P46–BRCA (OS)

Open the BRCA breakdown →