DNM1P46

Across TCGA pan-cancer cohorts, DNM1P46 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DNM1P46’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DNM1P46 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DNM1P46 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

KIRC, THCA, and BLCA are the cancer types where DNM1P46 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNM1P46 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.385	<.001	11	view →
THCA	Male	All	−0.755	<.001	10	view →
BLCA	Male	All	−0.524	<.001	10	view →
LUAD	All	III,IV	−0.275	<.001	9	view →
LUSC	Male	II,III,IV	−0.404	<.001	7	view →
UCEC	All	II,III,IV	−0.493	<.001	6	view →
BRCA	All	III,IV	−0.373	<.001	6	view →
LIHC	All	All	+0.110	.002	6	view →
KICH	All	All	−0.354	<.001	5	view →
COAD	Female	All	−0.116	.002	4	view →
PRAD	All	All	−0.245	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DNM1P46–KIRC

Open the KIRC breakdown →