DNM1P46

Across TCGA patient cohorts, DNM1P46 mutation is significantly associated with the RNA expression of many other genes, with 303 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNM1P46-associated genes across cancer lineages are RNU6-383P, RN7SKP153, and RNA5SP393. Each is linked with DNM1P46 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNM1P46-to-partner and partner-to-DNM1P46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-383P grouped by DNM1P46-low versus DNM1P46-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNM1P46→partner) and Y-score (partner→DNM1P46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNU6-383P →	+0.368	+7.977	<.001	.007	3	2
LUAD	RN7SKP153 →	+0.149	+4.198	.002	.003	3	2
UCEC	RNA5SP393 →	+0.394	+3.088	<.001	.001	3	2
UCEC	RNA5SP422 →	+1.044	+2.408	<.001	.009	3	2
HNSC	RNU4-70P →	+0.643	+7.954	<.001	.008	3	2
SKCM	SMAD1-AS1 →	+0.072	+5.993	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 303 associations by consensus.

RNU6-383P by DNM1P46 expression — LGG

Explore this box plot interactively →