DNM1P34

Across TCGA patient cohorts, DNM1P34 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNM1P34-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and JNK2. Each is linked with DNM1P34 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNM1P34-to-partner and partner-to-DNM1P34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by DNM1P34-low versus DNM1P34-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNM1P34→partner) and Y-score (partner→DNM1P34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.397	-2.999	.001	.035	3	1
UCEC	INPP4B →	-0.388	-3.169	.016	.018	3	1
UCEC	JNK2 →	+0.347	+2.321	<.001	.035	3	1
UCEC	Ku80 →	+0.297	+3.013	.012	.018	3	1
UCEC	MAPK_pT202_Y204 →	-0.592	-2.321	.012	.035	3	1
UCEC	NDRG1_pT346 →	-0.625	-3.321	.011	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

EGFR_pY1068 by DNM1P34 expression — UCEC

Explore this box plot interactively →