Across TCGA cell cohorts, DNLZ mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DNLZ-associated genes across cancer lineages are GFRA4, CABS1, and PIGY. Each is linked with DNLZ in more than 1 cancer types. Because this analysis shows association rather than direction, both DNLZ-to-partner and partner-to-DNLZ results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNLZ→partner) and Y-score (partner→DNLZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GFRA4 →	+0.036	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	CABS1 →	+0.019	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PIGY →	+2.009	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

DNLZ survival (RNA) · tumor vs normal (RNA) · all DNLZ data types