DNHD1

Across TCGA patient cohorts, DNHD1 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNHD1-associated genes across cancer lineages are ATM, TFRC, and ASNS. Each is linked with DNHD1 in more than 4 cancer types. Because this analysis shows association rather than direction, both DNHD1-to-partner and partner-to-DNHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DNHD1-low versus DNHD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNHD1→partner) and Y-score (partner→DNHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.367	-1.709	<.001	<.001	3	5
COAD	TFRC →	+0.409	+1.734	.008	.021	3	4
COAD	ASNS →	+0.419	+2.906	<.001	.001	3	4
BRCA	Heregulin →	+0.265	+2.611	<.001	.006	3	3
BRCA	PDK1_pS241 →	-0.339	-3.000	<.001	.037	3	3
BRCA	4E-BP1_pT70 →	+0.174	+2.584	.035	.012	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

ATM by DNHD1 expression — UCEC

Explore this box plot interactively →