DNHD1

Across TCGA pan-cancer cohorts, DNHD1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated DNHD1 data layer compared with 10 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DNHD1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNHD1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

KIRC, HNSC, and ACC are the cancer types where DNHD1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.496	0.713	<.001	122	view →
HNSC	OS	Tertile	All	0.853	0.700	<.001	103	view →
ACC	DFS	Tertile	All	0.260	0.691	<.001	86	view →
SKCM	OS	Quartile	II,III,IV	0.593	0.260	<.001	49	view →
COAD	OS	Tertile	All	0.821	0.909	.001	49	view →
KICH	DFS	Quartile	III,IV	0.189	0.885	.005	42	view →
READ	OS	Median	All	0.797	0.333	.001	41	view →
UCEC	OS	Quartile	IV	0.779	0.251	.006	26	view →
PRAD	DFS	Tertile	All	0.810	0.921	.001	22	view →
THCA	OS	Quartile	II,III,IV	0.584	0.913	.002	20	view →
KIRP	DFS	Median	All	0.363	0.720	.001	20	view →
LGG	DFS	Quartile	All	0.756	0.889	<.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

DNHD1–KIRC (DFS)

Open the KIRC breakdown →