DNHD1

Across TCGA cell cohorts, DNHD1 mutation is significantly associated with the RNA expression of many other genes, with 2,031 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNHD1-associated genes across cancer lineages are RPS19BP1, PDCD2, and KLK15. Each is linked with DNHD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DNHD1-to-partner and partner-to-DNHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS19BP1 grouped by DNHD1-low versus DNHD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNHD1→partner) and Y-score (partner→DNHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RPS19BP1 →	+0.417	+2.404	.006	.004	3	4
LARGE_INTESTINE	PDCD2 →	+0.390	+2.459	.005	.006	3	4
SOFT_TISSUE	KLK15 →	+0.063	+2.617	<.001	.004	3	3
UPPER_AERODIGESTIVE_TRACT	TAS2R9 →	+0.023	+2.700	<.001	.001	3	3
LARGE_INTESTINE	EIF3L →	+0.551	+3.672	<.001	<.001	3	3
LARGE_INTESTINE	PLTP →	-1.590	-1.722	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,031 associations by consensus.

RPS19BP1 by DNHD1 expression — LARGE_INTESTINE

Explore this box plot interactively →