Across TCGA cell cohorts, DNER mutation is significantly associated with the mutation status of many other genes, with 4,898 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNER-associated genes across cancer lineages are KMT2B, SI, and PLXNB1. Each is linked with DNER in more than 4 cancer types. Because this analysis shows association rather than direction, both DNER-to-partner and partner-to-DNER results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNER→partner) and Y-score (partner→DNER) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KMT2B →	+2.308	+2.884	.009	.009	1	5
LARGE_INTESTINE	SI →	+2.032	+2.963	<.001	<.001	1	5
BLOOD_Lymphoma	PLXNB1 →	+2.969	+3.337	.009	.009	1	4
BLOOD_Leukemia	AKAP13 →	+2.672	+4.225	.008	.008	1	4
BLOOD_Leukemia	INSR →	+3.157	+4.665	.003	.003	1	4
SOFT_TISSUE	KEL →	+5.502	+5.502	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,898 associations by consensus.

Exploration

DNER survival (RNA) · tumor vs normal (RNA) · all DNER data types