DND1

Across TCGA patient cohorts, DND1 RNA expression is significantly associated with the go_rna of many other GO terms, with 990 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible DND1-associated GO terms across cancer lineages are Centriole elongation, Mitochondrial ribosome assembly, and Reticulophagy. Each is linked with DND1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DND1-to-partner and partner-to-DND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centriole elongation grouped by DND1-low versus DND1-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DND1→partner) and Y-score (partner→DND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Centriole elongation →	+0.096	+0.536	<.001	.002	3	1
SCLC	Mitochondrial ribosome assembly →	-0.140	-0.669	<.001	.001	3	1
SCLC	Reticulophagy →	+0.130	+0.934	<.001	<.001	3	1
SCLC	Telomeric D-loop disassembly →	+0.132	+0.839	<.001	<.001	3	1
SCLC	Pyrimidine nucleobase metabolic process →	+0.124	+0.693	<.001	<.001	3	1
SCLC	DCMP catabolic process →	-0.732	-0.613	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 990 associations by consensus.

Centriole elongation by DND1 expression — SCLC

Explore this box plot interactively →