DND1

Across TCGA cell cohorts, DND1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,399 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DND1-associated GO terms across cancer lineages are Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, Leukotriene signaling pathway, and Microtubule polymerization. Each is linked with DND1 in more than 13 cancer types. Because this analysis shows association rather than direction, both DND1-to-partner and partner-to-DND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by DND1-low versus DND1-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DND1→partner) and Y-score (partner→DND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.112	+0.154	<.001	.001	3	14
OESOPHAGUS	Leukotriene signaling pathway →	+1.456	+0.190	<.001	.002	3	12
BLOOD_Leukemia	Microtubule polymerization →	+0.106	+0.300	<.001	<.001	3	11
BONE	mRNA splice site recognition →	+0.105	+0.215	<.001	<.001	2	12
BLOOD_Leukemia	Microtubule nucleation →	+0.111	+0.291	<.001	<.001	3	11
URINARY_TRACT	Negative regulation of DNA-templated transcription, elongation →	+0.099	+0.223	<.001	.005	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,399 associations by consensus.

Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I by DND1 expression — CNS

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