DNASE1L3

Across TCGA pan-cancer cohorts, DNASE1L3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DNASE1L3 data layer compared with 30 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DNASE1L3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DNASE1L3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where DNASE1L3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.310	0.821	.003	22	view →
CCRCC	DFS	Tertile	All	0.878	0.554	.014	3	view →
LSCC	DFS	Quartile	III,IV	0.967	0.425	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DNASE1L3–LUAD (OS)

Open the LUAD breakdown →