DNASE1L3

Across TCGA pan-cancer cohorts, DNASE1L3 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of DNASE1L3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DNASE1L3 RNA is repressed in tumor relative to normal tissue. In most cancer types DNASE1L3 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and BLCA are the cancer types where DNASE1L3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNASE1L3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−3.610	<.001	12	view →
KIRC	Female	IV	−3.031	<.001	12	view →
BLCA	All	All	−1.697	<.001	12	view →
KICH	Male	IV	−4.820	<.001	11	view →
KIRP	Female	II,III,IV	−4.078	<.001	11	view →
HNSC	All	II,III,IV	−1.493	<.001	10	view →
LUAD	Female	III,IV	−3.654	<.001	9	view →
LUSC	Female	II,III,IV	−3.297	<.001	9	view →
LIHC	Male	III,IV	−3.077	<.001	9	view →
THCA	Male	III,IV	−2.485	<.001	9	view →
UCEC	All	III,IV	−1.432	<.001	8	view →
BRCA	All	III,IV	−2.165	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

DNASE1L3–COAD

Open the COAD breakdown →