DNASE1L3

Across TCGA patient cohorts, DNASE1L3 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,807 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible DNASE1L3-associated proteins across cancer lineages are GIMAP7, GIMAP8, and SEPTIN1. Each is linked with DNASE1L3 in more than 8 cancer types. Because this analysis shows association rather than direction, both DNASE1L3-to-partner and partner-to-DNASE1L3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DNASE1L3 versus GIMAP7 in HNSC, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE1L3→partner) and Y-score (partner→DNASE1L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GIMAP7 →	+0.456	+0.957	<.001	<.001	3	9
UCEC	GIMAP8 →	+0.759	+0.735	<.001	<.001	3	9
BRCA	SEPTIN1 →	+0.820	+0.716	<.001	<.001	3	8
UCEC	ADA2 →	+0.757	+0.877	<.001	<.001	3	8
UCEC	CLIC2 →	+0.780	+0.670	<.001	<.001	3	8
OV	DOK2 →	+0.661	+0.508	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,807 associations by consensus.

DNASE1L3 vs GIMAP7 — HNSC

Explore this scatter interactively →