DNASE1L3

Across TCGA patient cohorts, DNASE1L3 protein abundance is significantly associated with the RNA expression of many other genes, with 903 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible DNASE1L3-associated genes across cancer lineages are IPO13, ASAH1, and RASD1. Each is linked with DNASE1L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNASE1L3-to-partner and partner-to-DNASE1L3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DNASE1L3 versus IPO13 in LUAD, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE1L3→partner) and Y-score (partner→DNASE1L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IPO13 →	-0.528	-0.757	.001	.002	3	2
LSCC	ASAH1 →	+0.513	+1.065	.008	.002	3	2
CCRCC	RASD1 →	+1.285	+0.615	.005	.004	3	2
CCRCC	SPRY1 →	+1.222	+0.635	.001	.003	3	2
LUAD	PLAT →	-1.435	-1.029	.004	.001	3	1
LUAD	LIMK1 →	-0.665	-0.589	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 903 associations by consensus.

DNASE1L3 vs IPO13 — LUAD

Explore this scatter interactively →