DNASE1L3

Across TCGA patient cohorts, DNASE1L3 mutation is significantly associated with the RNA expression of many other genes, with 2,167 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNASE1L3-associated genes across cancer lineages are MIR4652, PCAT19, and MIR516A1. Each is linked with DNASE1L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNASE1L3-to-partner and partner-to-DNASE1L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4652 grouped by DNASE1L3-low versus DNASE1L3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE1L3→partner) and Y-score (partner→DNASE1L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4652 →	+0.284	+4.479	.001	.007	3	2
UCEC	PCAT19 →	-0.939	-3.459	.003	.005	3	2
BLCA	MIR516A1 →	+0.341	+6.484	<.001	<.001	3	2
UCEC	CRYBB2P1 →	+0.519	+3.021	.001	<.001	3	2
UCEC	RRN3P2 →	-0.395	-3.375	.009	.005	3	2
UCEC	FGF21 →	+0.445	+2.983	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,167 associations by consensus.

MIR4652 by DNASE1L3 expression — BRCA

Explore this box plot interactively →