DNASE1L3

Across TCGA cell cohorts, DNASE1L3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,462 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DNASE1L3-associated GO terms across cancer lineages are Protein-RNA complex assembly, Vitamin E metabolic process, and Transcription initiation at RNA polymerase II promoter. Each is linked with DNASE1L3 in more than 5 cancer types. Because this analysis shows association rather than direction, both DNASE1L3-to-partner and partner-to-DNASE1L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-RNA complex assembly grouped by DNASE1L3-low versus DNASE1L3-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE1L3→partner) and Y-score (partner→DNASE1L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Protein-RNA complex assembly →	+0.038	+0.077	.002	.008	3	6
BLOOD_Lymphoma	Vitamin E metabolic process →	-0.568	-0.925	.002	.002	3	5
BREAST	Transcription initiation at RNA polymerase II promoter →	+0.042	+0.079	<.001	.006	3	5
BREAST	Protein-RNA complex organization →	+0.036	+0.083	.003	.004	2	6
PANCREAS	Cell recognition →	-0.091	-0.148	<.001	.004	3	4
BLOOD_Lymphoma	Peptide secretion →	-0.052	-0.819	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,462 associations by consensus.

Protein-RNA complex assembly by DNASE1L3 expression — BREAST

Explore this box plot interactively →