DNASE1L2

Across TCGA cell cohorts, DNASE1L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,714 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DNASE1L2-associated GO terms across cancer lineages are Calcium-independent cell-matrix adhesion, Sperm motility, and Subtelomeric heterochromatin formation. Each is linked with DNASE1L2 in more than 10 cancer types. Because this analysis shows association rather than direction, both DNASE1L2-to-partner and partner-to-DNASE1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Calcium-independent cell-matrix adhesion grouped by DNASE1L2-low versus DNASE1L2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE1L2→partner) and Y-score (partner→DNASE1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Calcium-independent cell-matrix adhesion →	+0.161	+0.606	.005	<.001	3	11
BREAST	Sperm motility →	-0.089	-0.927	<.001	<.001	3	9
LARGE_INTESTINE	Subtelomeric heterochromatin formation →	+0.101	+0.536	<.001	<.001	3	9
OESOPHAGUS	mRNA splice site recognition →	+0.130	+0.690	<.001	<.001	3	9
SOFT_TISSUE	Double-strand break repair via single-strand annealing →	+0.066	+0.615	.001	.002	2	10
OESOPHAGUS	Methylglyoxal metabolic process →	+0.147	+0.722	.002	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,714 associations by consensus.

Calcium-independent cell-matrix adhesion by DNASE1L2 expression — BONE

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