DNASE1L2

Across TCGA pan-cancer cohorts, DNASE1L2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated DNASE1L2 data layer compared with 1 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher DNASE1L2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DNASE1L2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and STAD show a favorable association.

MESO, KIRC, and SKCM are the cancer types where DNASE1L2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.173	0.462	<.001	117	view →
KIRC	DFS	Median	II,III,IV	0.413	0.624	<.001	87	view →
SKCM	DFS	Median	All	0.807	0.648	<.001	78	view →
KIRP	DFS	Median	All	0.776	1.000	<.001	65	view →
ACC	DFS	Tertile	All	0.361	0.763	<.001	61	view →
UVM	DFS	Median	All	0.330	0.741	.001	51	view →
STAD	OS	Tertile	II,III,IV	0.873	0.593	.003	47	view →
UCS	OS	Tertile	IV	0.141	1.000	.024	30	view →
PRAD	DFS	Median	All	0.699	0.894	<.001	30	view →
COAD	OS	Median	IV	0.405	0.859	.007	28	view →
PAAD	OS	Tertile	All	0.688	0.388	.011	19	view →
THYM	OS	Median	II,III,IV	1.000	0.883	.007	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

DNASE1L2–MESO (OS)

Open the MESO breakdown →