DNASE1L2

Across TCGA cell cohorts, DNASE1L2 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNASE1L2-associated genes across cancer lineages are LHCGR, SLC10A6, and SLAMF8. Each is linked with DNASE1L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNASE1L2-to-partner and partner-to-DNASE1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LHCGR grouped by DNASE1L2-low versus DNASE1L2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE1L2→partner) and Y-score (partner→DNASE1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LHCGR →	+0.028	+2.560	<.001	.008	3	1
LARGE_INTESTINE	SLC10A6 →	+0.367	+3.389	.003	.007	3	1
LARGE_INTESTINE	SLAMF8 →	+0.108	+2.869	<.001	.008	3	1
LARGE_INTESTINE	GABRG1 →	+0.008	+3.196	.001	<.001	3	1
LARGE_INTESTINE	SIGLECL1 →	+0.011	+2.977	<.001	.006	3	1
LARGE_INTESTINE	KRTAP19-5 →	+0.129	+2.669	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

LHCGR by DNASE1L2 expression — LARGE_INTESTINE

Explore this box plot interactively →