DNALI1

Across TCGA cell cohorts, DNALI1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DNALI1-associated genes across cancer lineages are MT1B, OXT, and AVPR1B. Each is linked with DNALI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNALI1-to-partner and partner-to-DNALI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MT1B grouped by DNALI1-low versus DNALI1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNALI1→partner) and Y-score (partner→DNALI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MT1B →	+0.302	+4.054	.002	.004	3	1
SKIN	OXT →	+0.063	+4.977	<.001	.007	3	1
SKIN	AVPR1B →	+0.006	+5.415	.007	.004	3	1
LUNG_NSCLC_LUAD	OR1L6 →	+0.019	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR13C8 →	+0.032	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR10G4 →	+0.012	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MT1B by DNALI1 expression — LARGE_INTESTINE

Explore this box plot interactively →