DNAL4

Across TCGA pan-cancer cohorts, DNAL4 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of DNAL4’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where DNAL4 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types DNAL4 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

CCRCC, LUAD, and PDAC are the cancer types where DNAL4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAL4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+0.504	<.001	10	view →
LUAD	Female	All	−0.336	<.001	3	view →
PDAC	All	All	+0.296	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

DNAL4–CCRCC

Open the CCRCC breakdown →