DNAL4

Across TCGA pan-cancer cohorts, DNAL4 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DNAL4 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher DNAL4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DNAL4 expression acts as an unfavorable survival marker, although some lineages such as UVM and LUSC show a favorable association.

KICH, ACC, and LIHC are the cancer types where DNAL4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	III,IV	0.347	0.942	.001	76	view →
ACC	DFS	Median	All	0.206	0.705	<.001	70	view →
LIHC	DFS	Median	All	0.359	0.509	<.001	61	view →
UVM	DFS	Quartile	All	0.860	0.519	.003	49	view →
LUSC	DFS	Median	II,III,IV	0.871	0.585	.006	24	view →
BRCA	OS	Tertile	IV	0.820	0.196	.002	21	view →
THYM	DFS	Tertile	All	0.972	0.656	.001	19	view →
UCEC	OS	Quartile	III,IV	0.675	0.371	.006	18	view →
THCA	DFS	Median	IV	0.451	0.865	.002	17	view →
KIRC	OS	Tertile	All	0.717	0.531	.007	16	view →
ESCA	DFS	Quartile	II,III,IV	1.000	0.255	.006	13	view →
PAAD	OS	Median	III,IV	0.629	1.000	.022	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DNAL4–KICH (OS)

Open the KICH breakdown →