DNAL1

Across TCGA pan-cancer cohorts, DNAL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DNAL1 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DNAL1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNAL1 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

LSCC, GBM, and CCRCC are the cancer types where DNAL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.873	0.999	.001	19	view →
GBM	DFS	Quartile	All	0.628	0.256	.001	11	view →
CCRCC	DFS	Median	III,IV	1.000	0.451	.032	5	view →
LUAD	DFS	Median	All	0.893	1.000	.019	2	view →
HNSC	DFS	Median	II,III,IV	0.975	0.909	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DNAL1–LSCC (DFS)

Open the LSCC breakdown →